The novel centers around the protagonist, Iris Chase, and her sister Laura, who committed suicide immediately after the Second World War. Iris, now an old woman, recalls the events and relationships of her childhood, youth and middle age, as well as her unhappy marriage to Richard Griffen, a rival of her industrialist father. Interwoven into the novel is a story within a story, a roman ? clef attributed to Laura and published by Iris about Alex Thomas, a politically radical author of pulp science fiction who has an ambiguous relationship with the sisters. That novel itself contains a story within a story, the eponymous Blind Assassin, a science fiction story told by Alex's fictional counterpart to that novel's protagonist, believed to be Laura's fictional counterpart.