This edition delivers strategies for understanding, diagnosing and managing disease. Hundreds of renowned clinicians and investigators report key advances seen across the specialties of internal medicine and discuss a wide range of topical issues, including ethics, disease prevention and genetics. With more than 90 new chapters, it presents coverage of: alternative medicine; practice guidelines; the impact of genetics on clinical practice; infertility and fertility control; adolescent health care; gene therapy; and the latest treatment strategies from the world's leading experts. Features include: expanded sections on treatment; more colour illustrations and high quality images; additional clinical guidelines and tables; genetic considerations highlighted by icons; and acronym boxes.